Researchers have characterized DNA damage (as seen by green staining in panel A and B) as well as invasion of epithelial cells into underlying tissue (panel C) as a result of irradiation. Their ongoing work with these model systems will provide insight into the mechanisms by which radiation drives cancerous changes in cells, thereby allowing for more accurate cancer risk assessment in astronauts.
A) Cells in 2D Monolayers
B) Cells in 3D Spheroids
C) Cells in 3D Organotypic Model